Polynucleotides for skin quality
Polynucleotides are biostimulating injections that improve skin quality rather than adding volume. They are primarily used on thin and sensitive skin, such as around the eyes and on the neck.
What are polynucleotides?
Polynucleotides are highly purified fragments of DNA. Through an extensive purification process, only the fragmented DNA remains, without cellular material or proteins. The result is an injectable, highly tolerable gel.
It is explicitly not a filler. Polynucleotides are not used to fill a fold or restore a contour, but to help the skin itself function better: better hydrated, more supple, and calmer.
How does it work?
After injection, polynucleotides form a network that attracts and retains water. This explains the relatively rapid sensation of better-hydrated skin.
More importantly, what happens in the following weeks. The DNA fragments act as a signal for fibroblasts, the cells responsible for collagen and elastin. These become more active, gradually improving the skin’s structure. Additionally, polynucleotides have anti-inflammatory properties and support microcirculation.
Who is this treatment suitable for?
- thin, dry, or tired skin
- fine lines and loss of elasticity
- the eye contour, where the skin is particularly thin and traditional fillers quickly become too heavy
- the neck, décolletage, and the inside of the upper arms
- sensitive or irritable skin, and after treatments that temporarily stress the skin
The treatment is less suitable for those expecting an immediate, clearly visible change, and for those whose primary issue is volume loss or sagging.
What happens during a session?
A consultation precedes the treatment. During this, the skin is assessed, medical history and medication are discussed, and expectations are evaluated. Please report any fish allergy, given the origin of the product.
On the day itself, the skin is cleansed and disinfected. Usually, an anesthetic cream is applied. Subsequently, the product is placed superficially into the skin using very fine needles or a blunt cannula, in a series of small depots.
The session typically lasts twenty to thirty minutes. Afterwards, small bumps are visible, which usually flatten out within a few hours to a day. Bruising is possible around the eyes.
Number of sessions and results
Polynucleotides are generally administered in a series of several sessions with a few weeks in between. The first change is usually experienced as better hydrated and more supple skin; the improvement in firmness and texture continues to build in the weeks and months following the final session.
Afterwards, the result is maintained with periodic sessions. Results vary from person to person; an obligation of means applies, rather than an obligation of result.
What this treatment does not do
- Polynucleotides do not provide volume. A sunken midface or a receding chin cannot be restored with them.
- They do not correct sagging. Excess eyelid skin, sagging cheeks, or loose neck skin require a surgical procedure.
- Deep static folds do not disappear.
- Dynamic wrinkles caused by facial expressions fall outside the scope of this treatment; botulinum toxin will be discussed for those.
Safety and contraindications
It is a well-tolerated product with a favorable safety profile. Transient symptoms include redness, small bumps, slight swelling, and occasionally a bruise.
The treatment is not performed during pregnancy or breastfeeding, in the presence of an active infection or inflammation in the area, with a known hypersensitivity or fish allergy, or during the active phase of an autoimmune disease.
Aftercare
- Touch the treated area as little as possible for the first few hours and do not apply makeup that day.
- Avoid saunas, steam rooms, tanning beds, and intense exercise for two days.
- Protect the skin from the sun with a high protection factor.
- Refrain from using active skincare products containing acids or retinol for a few days.
Combination with surgery and other treatments
Polynucleotides combine well with botulinum toxin, fillers, biostimulators, and with PRP or microneedling. Following an eyelid correction, they are a valuable part of a regenerative aftercare trajectory: surgery restores the shape, while this treatment works on the quality of the surrounding skin.
Frequently asked questions
Are polynucleotides the same as a filler?
No. A filler adds volume using a cross-linked gel. Polynucleotides stimulate the skin’s own repair mechanisms and do not provide volume.
How many sessions are needed?
Typically a series of several sessions with a few weeks in between. The exact number depends on the area and the condition of the skin.
When will the result become visible?
Hydration often improves quickly. The improvement in firmness and texture builds up over the weeks and months following the series.
Can the treatment be performed around the eyes?
Yes, that is one of the most requested areas. The work is performed superficially and with small quantities, adapted to the thin skin there.
Is the product safe in case of a fish allergy?
The treatment is not performed if there is a known fish allergy. Always report this during the consultation so that an alternative can be discussed.
Does this help with eye bags or loose eyelid skin?
The quality and firmness of the skin improve, but excess skin or fat protrusion are not corrected by this. An eyelid correction will be discussed for those concerns.
Read also
This text is general in nature and does not replace personal medical advice. An obligation of means applies, not an obligation of results. What is possible in your situation is determined during a consultation and recorded in writing. Read the full medical disclaimer.
Schedule your personal consultation
Discover how we can enhance your well-being and self-confidence with our specialized care.