{"id":3352,"date":"2026-07-25T12:04:33","date_gmt":"2026-07-25T10:04:33","guid":{"rendered":"https:\/\/www.drcolle.be\/dienst\/biostimulators-for-natural-collagen-production\/"},"modified":"2026-07-26T20:20:57","modified_gmt":"2026-07-26T18:20:57","slug":"biostimulators-for-natural-collagen-production","status":"publish","type":"dienst","link":"https:\/\/www.drcolle.be\/en\/dienst\/biostimulators-for-natural-collagen-production\/","title":{"rendered":"Biostimulators for natural collagen production"},"content":{"rendered":"\n<div class=\"wp-block-columns alignfull are-vertically-aligned-top is-layout-flex wp-container-core-columns-is-layout-b81f3336 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-top is-layout-flow wp-block-column-is-layout-flow\">\n<div class=\"wp-block-cover has-custom-content-position is-position-bottom-center\" style=\"padding-top:var(--wp--preset--spacing--128-65);padding-bottom:var(--wp--preset--spacing--64-32);min-height:560px;aspect-ratio:unset;\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1707\" class=\"wp-block-cover__image-background wp-image-4238 size-full\" alt=\"Close-up van hals en decollet\u00e9 \u2014 biostimulatoren bij dr. Julien Colle\" src=\"https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete.png\" data-object-fit=\"cover\" srcset=\"https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete.png 2560w, https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete-300x200.png 300w, https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete-1024x683.png 1024w, https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete-768x512.png 768w, https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete-1536x1024.png 1536w, https:\/\/www.drcolle.be\/wp-content\/uploads\/2026\/07\/huidverjonging-hals-en-decollete-2048x1366.png 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-100 has-background-dim wp-block-cover__gradient-background has-background-gradient has-header-overlay-gradient-background\"><\/span><div class=\"wp-block-cover__inner-container has-global-padding is-layout-constrained wp-block-cover-is-layout-constrained\">\n\n<div class=\"wp-block-group alignwide has-global-padding is-content-justification-left is-layout-constrained wp-container-core-group-is-layout-e896cbe3 wp-block-group-is-layout-constrained\">\n\n<h1 class=\"wp-block-heading\">Biostimulators for natural collagen production<\/h1>\n\n\n<p class=\"is-style-default wp-block-paragraph\">Biostimulators stimulate the body to produce its own collagen, gradually making the skin firmer. The effect builds up over weeks to months and therefore requires patience and a well-considered plan. <\/p>\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\" style=\"margin-top:var(--wp--preset--spacing--24-16)\">\n\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/agenda.mediris.be\/appointments?agenda=5a9f0a87-cb2f-460c-9e5d-f2eb27b69c94&amp;careprovider=e46d1dc1-89af-430c-b647-9b95d15ad5ba\" target=\"_blank\" rel=\"noopener\">Make an appointment<\/a><\/div>\n\n<\/div>\n\n<\/div>\n\n<\/div><\/div>\n<\/div>\n<\/div>\n\n<h2 id=\"wat-zijn-biostimulatoren\" class=\"wp-block-heading\">What are biostimulators?<\/h2>\n\n<p class=\"wp-block-paragraph\">Biostimulators are injectable products that are not primarily intended to occupy space, but to trigger a reaction from the body. The best-known examples are poly-L-lactic acid and calcium hydroxylapatite. Both substances have long been used in medicine and are biodegradable.  <\/p>\n\n<p class=\"wp-block-paragraph\">The distinction from a classic filler is fundamental. A filler provides volume because the gel itself occupies space. A biostimulator provides firmness over time because the body creates new supporting tissue around the injected material. The visible result therefore consists of the body&#8217;s own collagen.   <\/p>\n\n<h2 id=\"hoe-werkt-het\" class=\"wp-block-heading\">How does it work?<\/h2>\n\n<p class=\"wp-block-paragraph\">After injection into the deeper layers of the skin or the subcutaneous tissue, the product triggers a controlled, mild tissue reaction. Fibroblasts are activated and begin to produce new collagen around the particles. <\/p>\n\n<p class=\"wp-block-paragraph\">As the product is broken down, the newly formed collagen network takes over. The skin becomes thicker, firmer, and more resilient, and the face appears fuller without any gel remaining. <\/p>\n\n<p class=\"wp-block-paragraph\">The first visible improvement is usually noticed after a few weeks, and the result continues to build over several months. Because it involves the body&#8217;s own collagen, the result lasts longer than with a classic filler. <\/p>\n\n<h2 id=\"voor-wie-is-deze-behandeling-geschikt\" class=\"wp-block-heading\">Who is this treatment suitable for?<\/h2>\n\n<p class=\"wp-block-paragraph\">The treatment is indicated for a general loss of skin firmness and density, rather than for a single defined fold. Typical areas include the cheeks and temples, the jawline, the neck and d\u00e9colletage, and body areas such as the inside of the upper arms, the abdomen, or the knees. <\/p>\n\n<p class=\"wp-block-paragraph\">It is also an option for those who prefer a gradual, subtle change over an immediately visible correction. Those who expect to see a visible difference after a single session will be disappointed. <\/p>\n\n<h2 id=\"hoe-verloopt-een-sessie\" class=\"wp-block-heading\">What happens during a session?<\/h2>\n\n<p class=\"wp-block-paragraph\">During the consultation, the skin and tissue are assessed, medical history and medication are discussed, and expectations are evaluated, with particular attention to the timeline of the results. A reflection period is provided. <\/p>\n\n<p class=\"wp-block-paragraph\">On the day itself, the product is prepared according to instructions, which requires preparation time for certain biostimulators. The skin is disinfected, and usually, an anesthetic cream or local anesthesia is used. The product is distributed across the area using a needle or blunt cannula, in several small amounts and at the correct depth.  <\/p>\n\n<p class=\"wp-block-paragraph\">After the injections, the area is massaged to distribute the product evenly. A session typically lasts thirty to forty-five minutes. <\/p>\n\n<h2 id=\"aantal-sessies-en-resultaat\" class=\"wp-block-heading\">Number of sessions and results<\/h2>\n\n<p class=\"wp-block-paragraph\">Usually several sessions are required, with an interval of several weeks to several months. Each session builds upon the previous one. <\/p>\n\n<p class=\"wp-block-paragraph\">Part of the swelling immediately after the treatment gives a temporary fuller appearance. This is not the result, but fluid, and it disappears within a few days. The actual result becomes visible after a few weeks and reaches its peak after several months. There is an obligation of effort and not an obligation of result.   <\/p>\n\n<h2 id=\"wat-deze-behandeling-niet-doet\" class=\"wp-block-heading\">What this treatment does not do<\/h2>\n\n<ul class=\"wp-block-list\">\n<li>Biostimulators do not provide immediate volume gain.<\/li>\n\n\n\n<li>They are not suitable for the precise correction of a small area, such as the lips. A <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/hyaluronic-acid-fillers\/\">hyaluronic acid filler<\/a> is indicated for that purpose. <\/li>\n\n\n\n<li>They do not correct sagging and do not replace a <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/facelift\/\">facelift<\/a>, <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/neck-lift\/\">neck lift<\/a>, or eyelid surgery.<\/li>\n\n\n\n<li>They do not work on dynamic wrinkles caused by facial expressions.<\/li>\n\n\n\n<li><strong>They are not dissolvable<\/strong> like hyaluronic acid. This makes careful indication and conservative dosing all the more important. <\/li>\n<\/ul>\n\n<h2 id=\"veiligheid-en-contra-indicaties\" class=\"wp-block-heading\">Safety and contraindications<\/h2>\n\n<p class=\"wp-block-paragraph\">The treatment is performed by a physician with knowledge of anatomy and the correct injection depth. Injecting too superficially increases the risk of visible irregularities. <\/p>\n\n<p class=\"wp-block-paragraph\">Transient symptoms include swelling, redness, tenderness, and bruising. Small nodules are possible, usually months after the treatment; correct technique and meticulous aftercare massage limit this risk. Vascular occlusion is rare but serious.  <\/p>\n\n<p class=\"wp-block-paragraph\">The treatment is not performed during pregnancy or breastfeeding, in the presence of an active infection in the area, known hypersensitivity, a tendency toward keloid formation, or an autoimmune disease in the active phase.<\/p>\n\n<h2 id=\"nazorg\" class=\"wp-block-heading\">Aftercare<\/h2>\n\n<ul class=\"wp-block-list\">\n<li>With certain biostimulators, you will be asked to massage the area yourself several times a day for a few days, according to a schedule provided to you.<\/li>\n\n\n\n<li>Avoid saunas, steam rooms, tanning beds, and intense exercise for two days.<\/li>\n\n\n\n<li>Protect the skin from the sun and drink plenty of water.<\/li>\n\n\n\n<li>Contact us in case of increasing pain, skin discoloration, or a palpable lump that does not disappear.<\/li>\n<\/ul>\n\n<h2 id=\"combinatie-met-chirurgie-en-andere-behandelingen\" class=\"wp-block-heading\">Combination with surgery and other treatments<\/h2>\n\n<p class=\"wp-block-paragraph\">Biostimulators are regularly combined with <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/botulinum-toxin-for-dynamic-wrinkles\/\">botulinum toxin<\/a>, <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/hyaluronic-acid-fillers\/\">fillers<\/a>, <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/polynucleotides-for-skin-quality\/\">polynucleotides<\/a>, or <a href=\"https:\/\/www.drcolle.be\/en\/dienst\/facial-prp-treatment\/\">PRP<\/a>. Around a surgical procedure, they can prepare the tissue quality or support the result. When sagging is the primary concern, surgery is discussed first.  <\/p>\n\n<h2 id=\"veelgestelde-vragen\" class=\"wp-block-heading\">Frequently asked questions<\/h2>\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>What is the difference compared to a hyaluronic acid filler?<\/summary>\n<p class=\"wp-block-paragraph\">A filler provides immediate volume because the gel itself occupies space. A biostimulator stimulates the body to produce its own collagen, allowing the result to build up gradually. <\/p>\n<\/details>\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>When will I see results?<\/summary>\n<p class=\"wp-block-paragraph\">The first improvement is usually noticed after a few weeks, and the result continues to build over several months. Immediate change is not part of this treatment. <\/p>\n<\/details>\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>How long does the result last?<\/summary>\n<p class=\"wp-block-paragraph\">Longer than with a classic filler, because it involves the body&#8217;s own collagen. The exact duration varies individually. <\/p>\n<\/details>\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Can the product be dissolved?<\/summary>\n<p class=\"wp-block-paragraph\">No. Unlike hyaluronic acid, a biostimulator cannot be dissolved with hyaluronidase. Therefore, the work is done conservatively and in stages.  <\/p>\n<\/details>\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Are biostimulators suitable for the lips?<\/summary>\n<p class=\"wp-block-paragraph\">No. For the lips, a hyaluronic acid filler is used. Biostimulators are intended for larger areas where skin firmness has decreased.  <\/p>\n<\/details>\n\n<details class=\"wp-block-details is-layout-flow wp-block-details-is-layout-flow\"><summary>Can this treatment replace a facelift?<\/summary>\n<p class=\"wp-block-paragraph\">No. In cases of pronounced sagging, more collagen does not change the position of the tissue. In such cases, a surgical procedure will be discussed.  <\/p>\n<\/details>\n\n<h2 id=\"lees-ook\" class=\"wp-block-heading\">Read also<\/h2>\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.drcolle.be\/en\/dienst\/skin-tightening-without-surgery\/\">Skin tightening without surgery<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.drcolle.be\/en\/dienst\/wrinkle-treatment\/\">Wrinkle treatment<\/a><\/li>\n<\/ul>\n\n<div class=\"wp-block-group medische-disclaimer has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\" style=\"border-top-style:solid;border-top-width:1px;margin-top:var(--wp--preset--spacing--48-32);padding-top:var(--wp--preset--spacing--24-16)\">\n<p class=\"has-link-color has-small-font-size wp-elements-7496b57ae5c3750201a4e0182fa89cd5 wp-block-paragraph\"><\/p><p class=\"has-small-font-size\" style=\"opacity:.7\">This text is general in nature and does not replace personal medical advice. An obligation of means applies, not an obligation of results. What is possible in your situation is determined during a consultation and recorded in writing. Read the full <a href=\"https:\/\/www.drcolle.be\/en\/medical-disclaimer\/\">medical disclaimer<\/a>.   <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>What are biostimulators? Biostimulators are injectable products that are not primarily intended to occupy space, but to trigger a reaction from the body. The best-known examples are poly-L-lactic acid and calcium hydroxylapatite. Both substances have long been used in medicine and are biodegradable. The distinction from a classic filler is fundamental. A filler provides volume [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":"","rank_math_title":"Biostimulators: 3 steps and recovery | dr. Colle, specialist","rank_math_description":"Biostimulators stimulate the skin to produce its own collagen. Discover the process, the treatment plan, and the difference from fillers with specialist dr. Julien Colle. 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